Where history, hospitality, and community come together.

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Welcome to the

Neighborhood

  • Sissy’s Children’s Boutique

    136 E. Mantissa Row

  • Coastal Sports Cards

    104 E. College Ave

  • Community Health

    107 W. College Ave

  • Pour Friends - Coffee, Cream, & Crumbs

    108 E. College Ave

  • Nutrition on 5th

    122 N. Fifth St

  • Jazzy Blues 843

    119 W. Carolina Ave

What’s Happening on Main Street

We visited one of the newest Main Street Hartsville gems, Marcella’s Italian Restaurant , for lunch yesterday, and let me tell you, they absolutely knocked it out of the park. The experience was full of delicious food, cozy atmosphere, and ste
Main Street Hartsville is spreading the love. Coming soon, Love Local Letters invites our community to write notes of appreciation to downtown businesses and employees. Join us in celebrating the people who make Hartsville feel like home. #loveloca
Happy New Year from Main Street Hartsville! #HappyNewYear #happynewyear2026 #hartsvilleSC #MainstreetHartsville #DowntownHartsville
Merry Christmas from Main Street Hartsville! #MerryChristmas #HartsvilleSC #HartsvilleHolidays #MainStreetHartsville #DowntownHartsville #HappyHolidays